Polycomb Responds to Low Levels of Transcription

Polycomb Responds to Low Levels of Transcription

How is Polycomb (Pc), a eukaryotic negative regulator of transcription, targeted to specific mammalian genes? Our genome-wide analysis of the Pc mark H3K27me3 in murine cells revealed that Pc is preferentially associated with CpG island promoters of genes that are transcribed at a low level and less...

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Bibliographic Details
Main Authors: Georgina Berrozpe, Gene O. Bryant, Katherine Warpinski, Dan Spagna, Santosh Narayan, Shivangi Shah, Mark Ptashne
Format: Article
Language:English
Published: Elsevier 2017-07-01
Series:Cell Reports
Subjects:
Polycomb
Kit gene
genome-wide
transcription
CpG island promoters
CRISPR
shRAD21
enhancers
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717309075

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http://www.sciencedirect.com/science/article/pii/S2211124717309075

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