ACE2-Independent Bat Sarbecovirus Entry and Replication in Human and Bat Cells

ABSTRACT Hundreds of sarbecoviruses have been found in bats, but only a fraction of them have the ability to infect cells using angiotensin-converting enzyme 2 (ACE2), the receptor for SARS-CoV and -2. To date, only ACE2-dependent sarbecoviruses have been isolated from field samples or grown in the...

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Bibliographic Details
Main Authors: Hua Guo, Ang Li, Tian-Yi Dong, Jia Su, Yu-Lin Yao, Yan Zhu, Zheng-Li Shi, Michael Letko
Format: Article
Language:English
Published: American Society for Microbiology 2022-12-01
Series:mBio
Subjects:
Online Access:https://journals.asm.org/doi/10.1128/mbio.02566-22