Predictive efficacy of low burden EGFR mutation detected by next-generation sequencing on response to EGFR tyrosine kinase inhibitors in non-small-cell lung carcinoma.

Predictive efficacy of low burden EGFR mutation detected by next-generation sequencing on response to EGFR tyrosine kinase inhibitors in non-small-cell lung carcinoma.

Direct sequencing remains the most widely used method for the detection of epidermal growth factor receptor (EGFR) mutations in lung cancer; however, its relatively low sensitivity limits its clinical use. The objective of this study was to investigate the sensitivity of detecting an epidermal growt...

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Bibliographic Details
Main Authors: Hye Sook Kim, Jae Sook Sung, Song-Ju Yang, Nak-Jung Kwon, LiHua Jin, Seung Tae Kim, Kyong Hwa Park, Sang Won Shin, Han Kyeom Kim, Jin-Hyoung Kang, Jeong-Oh Kim, Jae Yong Park, Jin Eun Choi, HyoungKyu Yoon, Chan Kwon Park, Kap-Seok Yang, Jeong-Sun Seo, Yeul Hong Kim
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3869671?pdf=render

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http://europepmc.org/articles/PMC3869671?pdf=render

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