ERα and ERβ Homodimers in the Same Cellular Context Regulate Distinct Transcriptomes and Functions

ERα and ERβ Homodimers in the Same Cellular Context Regulate Distinct Transcriptomes and Functions

The two estrogen receptors ERα and ERβ are nuclear receptors that bind estrogen (E2) and function as ligand-inducible transcription factors. They are homologues and can form dimers with each other and bind to the same estrogen-response element motifs in the DNA. ERα drives breast cancer growth where...

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Bibliographic Details
Main Authors: Dandan Song, Huan He, Rajitha Indukuri, Zhiqiang Huang, Lina Stepanauskaite, Indranil Sinha, Lars-Arne Haldosén, Chunyan Zhao, Cecilia Williams
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Endocrinology
Subjects:
estradiol (17ß-estradiol)
estrogen receptor beta (ERß)
estrogen receptor alpha (ERα)
RNA-Seq - RNA sequencing
cistrome
proliferation
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2022.930227/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2022.930227/full

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