Rapid host strain improvement by in vivo rearrangement of a synthetic yeast chromosome

The Sc2.0 project has built the Synthetic Chromosome Rearrangement and Modification by LoxP-mediated Evolution (SCRaMbLE) system into their synthetic chromosomes. Here the authors use SCRaMbLE to rapidly develop, diversify and screen strains for diverse production and growth characteristics.

Manylion Llyfryddiaeth
Prif Awduron: B. A. Blount, G-O. F. Gowers, J. C. H. Ho, R. Ledesma-Amaro, D. Jovicevic, R. M. McKiernan, Z. X. Xie, B. Z. Li, Y. J. Yuan, T. Ellis
Fformat: Erthygl
Iaith:English
Cyhoeddwyd: Nature Portfolio 2018-05-01
Cyfres:Nature Communications
Mynediad Ar-lein:https://doi.org/10.1038/s41467-018-03143-w