Dynamics of RNA Polymerase II Pausing and Bivalent Histone H3 Methylation during Neuronal Differentiation in Brain Development

Dynamics of RNA Polymerase II Pausing and Bivalent Histone H3 Methylation during Neuronal Differentiation in Brain Development

During cellular differentiation, genes important for differentiation are expected to be silent in stem/progenitor cells yet can be readily activated. RNA polymerase II (Pol II) pausing and bivalent chromatin marks are two paradigms suited for establishing such a poised state of gene expression; howe...

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Bibliographic Details
Main Authors: Jiancheng Liu, Xiwei Wu, Heying Zhang, Gerd P. Pfeifer, Qiang Lu
Format: Article
Language:English
Published: Elsevier 2017-08-01
Series:Cell Reports
Subjects:
Pol II pausing
pause release
H3K4me3
H3K27me3
bivalency
neuronal differentiation
cerebral cortical development
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717310252

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http://www.sciencedirect.com/science/article/pii/S2211124717310252

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