Effects of HLA single chain trimer design on peptide presentation and stability

Effects of HLA single chain trimer design on peptide presentation and stability

MHC class I “single-chain trimer” molecules, coupling MHC heavy chain, β2-microglobulin, and a specific peptide into a single polypeptide chain, are widely used in research. To more fully understand caveats associated with this design that may affect its use for basic and translational studies, we e...

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Bibliographic Details
Main Authors: Kathryn A. K. Finton, Peter B. Rupert, Della J. Friend, Ana Dinca, Erica S. Lovelace, Matthew Buerger, Domnita V. Rusnac, Ulysses Foote-McNabb, William Chour, James R. Heath, Jean S. Campbell, Robert H. Pierce, Roland K. Strong
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Immunology
Subjects:
human class I leukocyte antigens
HLA single-chain trimers
peptide presentation
pan-anti-class I antibodies
X-ray crystallography
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1170462/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2023.1170462/full

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