Human alveolar macrophage metabolism is compromised during Mycobacterium tuberculosis infection

Human alveolar macrophage metabolism is compromised during Mycobacterium tuberculosis infection

Pulmonary macrophages have two distinct ontogenies: long-lived embryonically-seeded alveolar macrophages (AM) and bone marrow-derived macrophages (BMDM). Here, we show that after infection with a virulent strain of Mycobacterium tuberculosis (H37Rv), primary murine AM exhibit a unique transcriptomic...

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Bibliographic Details
Main Authors: Laura E. Mendonca, Erwan Pernet, Nargis Khan, Joaquin Sanz, Eva Kaufmann, Jeffrey Downey, Alexandre Grant, Marianna Orlova, Erwin Schurr, Connie Krawczyk, Russell G. Jones, Luis B. Barreiro, Maziar Divangahi
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Immunology
Subjects:
tuberculosis
immunometabolism
immunity
pulmonary macrophages
metabolic reprograming
cell death programs
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1044592/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.1044592/full

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