Loading of Porous Functionalized Calcium Carbonate Microparticles: Distribution Analysis with Focused Ion Beam Electron Microscopy and Mercury Porosimetry

Loading of Porous Functionalized Calcium Carbonate Microparticles: Distribution Analysis with Focused Ion Beam Electron Microscopy and Mercury Porosimetry

Accurate analysis of intraparticle distribution of substances within porous drug carriers is important to optimize loading and subsequent processing. Mercury intrusion porosimetry, a common technique used for characterization of porous materials, assumes cylindrical pore geometry, which may lead to...

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Bibliographic Details
Main Authors: Maryam Farzan, Roger Roth, Gabriela Québatte, Joachim Schoelkopf, Jörg Huwyler, Maxim Puchkov
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:Pharmaceutics
Subjects:
porous drug carrier
functionalized calcium carbonate
drug loading
focused ion beam scanning electron microscopy
mercury intrusion porosimetry
dipalmitoylphosphatidylcholine
bovine serum albumin
Online Access:http://www.mdpi.com/1999-4923/11/1/32

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http://www.mdpi.com/1999-4923/11/1/32

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