hnRNPH1 recruits PTBP2 and SRSF3 to modulate alternative splicing in germ cells

Coordinated regulation of alternative splicing is essential for germ cell development. Here, the authors report that hnRNPH1 interacts with alternative splicing factors PTBP2 and SRSF3 in the germline to regulate pre-mRNA alternative splicing.

Bibliographic Details
Main Authors: Shenglei Feng, Jinmei Li, Hui Wen, Kuan Liu, Yiqian Gui, Yujiao Wen, Xiaoli Wang, Shuiqiao Yuan
Format: Article
Language:English
Published: Nature Portfolio 2022-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-31364-7