hnRNPH1 recruits PTBP2 and SRSF3 to modulate alternative splicing in germ cells
Coordinated regulation of alternative splicing is essential for germ cell development. Here, the authors report that hnRNPH1 interacts with alternative splicing factors PTBP2 and SRSF3 in the germline to regulate pre-mRNA alternative splicing.
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-31364-7 |
| _version_ | 1818545971097763840 |
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| author | Shenglei Feng Jinmei Li Hui Wen Kuan Liu Yiqian Gui Yujiao Wen Xiaoli Wang Shuiqiao Yuan |
| author_facet | Shenglei Feng Jinmei Li Hui Wen Kuan Liu Yiqian Gui Yujiao Wen Xiaoli Wang Shuiqiao Yuan |
| author_sort | Shenglei Feng |
| collection | DOAJ |
| description | Coordinated regulation of alternative splicing is essential for germ cell development. Here, the authors report that hnRNPH1 interacts with alternative splicing factors PTBP2 and SRSF3 in the germline to regulate pre-mRNA alternative splicing. |
| first_indexed | 2024-12-12T07:46:56Z |
| format | Article |
| id | doaj.art-738ecd8825e64db4b68fd36a5f294478 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-12T07:46:56Z |
| publishDate | 2022-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-738ecd8825e64db4b68fd36a5f2944782022-12-22T00:32:34ZengNature PortfolioNature Communications2041-17232022-06-0113111910.1038/s41467-022-31364-7hnRNPH1 recruits PTBP2 and SRSF3 to modulate alternative splicing in germ cellsShenglei Feng0Jinmei Li1Hui Wen2Kuan Liu3Yiqian Gui4Yujiao Wen5Xiaoli Wang6Shuiqiao Yuan7Institute Reproductive Health, Tongji Medical College, Huazhong University of Science and TechnologyInstitute Reproductive Health, Tongji Medical College, Huazhong University of Science and TechnologyInstitute Reproductive Health, Tongji Medical College, Huazhong University of Science and TechnologyInstitute Reproductive Health, Tongji Medical College, Huazhong University of Science and TechnologyInstitute Reproductive Health, Tongji Medical College, Huazhong University of Science and TechnologyInstitute Reproductive Health, Tongji Medical College, Huazhong University of Science and TechnologyInstitute Reproductive Health, Tongji Medical College, Huazhong University of Science and TechnologyInstitute Reproductive Health, Tongji Medical College, Huazhong University of Science and TechnologyCoordinated regulation of alternative splicing is essential for germ cell development. Here, the authors report that hnRNPH1 interacts with alternative splicing factors PTBP2 and SRSF3 in the germline to regulate pre-mRNA alternative splicing.https://doi.org/10.1038/s41467-022-31364-7 |
| spellingShingle | Shenglei Feng Jinmei Li Hui Wen Kuan Liu Yiqian Gui Yujiao Wen Xiaoli Wang Shuiqiao Yuan hnRNPH1 recruits PTBP2 and SRSF3 to modulate alternative splicing in germ cells Nature Communications |
| title | hnRNPH1 recruits PTBP2 and SRSF3 to modulate alternative splicing in germ cells |
| title_full | hnRNPH1 recruits PTBP2 and SRSF3 to modulate alternative splicing in germ cells |
| title_fullStr | hnRNPH1 recruits PTBP2 and SRSF3 to modulate alternative splicing in germ cells |
| title_full_unstemmed | hnRNPH1 recruits PTBP2 and SRSF3 to modulate alternative splicing in germ cells |
| title_short | hnRNPH1 recruits PTBP2 and SRSF3 to modulate alternative splicing in germ cells |
| title_sort | hnrnph1 recruits ptbp2 and srsf3 to modulate alternative splicing in germ cells |
| url | https://doi.org/10.1038/s41467-022-31364-7 |
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