The accuracy, feasibility and challenges of sequencing short tandem repeats using next-generation sequencing platforms.

To date we have little knowledge of how accurate next-generation sequencing (NGS) technologies are in sequencing repetitive sequences beyond known limitations to accurately sequence homopolymers. Only a handful of previous reports have evaluated the potential of NGS for sequencing short tandem repea...

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Bibliographic Details
Main Authors: Monika Zavodna, Andrew Bagshaw, Rudiger Brauning, Neil J Gemmell
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4250034?pdf=render