Orange-spotted grouper nervous necrosis virus-encoded protein A induces interferon expression via RIG-I/MDA5-MAVS-TBK1-IRF3 signaling in fish cells

Orange-spotted grouper nervous necrosis virus-encoded protein A induces interferon expression via RIG-I/MDA5-MAVS-TBK1-IRF3 signaling in fish cells

ABSTRACT Nervous necrosis virus (NNV), a highly contagious fish virus, has caused huge economic losses to the global aquaculture industry. A previous study showed that protein A (ProA) encoded by orange-spotted grouper NNV triggers type I interferon (IFN) production in fish cells, but the activation...

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Bibliographic Details
Main Authors: Siyou Huang, Yi Huang, Taowen Su, Runqing Huang, Lianpan Su, Yujia Wu, Shaoping Weng, Jianguo He, Junfeng Xie
Format: Article
Language:English
Published: American Society for Microbiology 2024-01-01
Series:Microbiology Spectrum
Subjects:
nervous necrosis virus
protein A
channel catfish
interferons
RLR signaling
RIG-I
Online Access:https://journals.asm.org/doi/10.1128/spectrum.04532-22

Internet

https://journals.asm.org/doi/10.1128/spectrum.04532-22

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