Lactate activation of α-cell KATP channels inhibits glucagon secretion by hyperpolarizing the membrane potential and reducing Ca2+ entry

Lactate activation of α-cell KATP channels inhibits glucagon secretion by hyperpolarizing the membrane potential and reducing Ca2+ entry

Objective: Elevations in pancreatic α-cell intracellular Ca2+ ([Ca2+]i) lead to glucagon (GCG) secretion. Although glucose inhibits GCG secretion, how lactate and pyruvate control α-cell Ca2+ handling is unknown. Lactate enters cells through monocarboxylate transporters (MCTs) and is also produced d...

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Bibliographic Details
Main Authors: Karolina E. Zaborska, Prasanna K. Dadi, Matthew T. Dickerson, Arya Y. Nakhe, Ariel S. Thorson, Charles M. Schaub, Sarah M. Graff, Jade E. Stanley, Roy S. Kondapavuluru, Jerod S. Denton, David A. Jacobson
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Molecular Metabolism
Subjects:
α-cells
Ca2+ handling
KATP channels
Glucagon secretion
Lactate
Pyruvate
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877820301307

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http://www.sciencedirect.com/science/article/pii/S2212877820301307

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