Single-Step Extraction Coupled with Targeted HILIC-MS/MS Approach for Comprehensive Analysis of Human Plasma Lipidome and Polar Metabolome

Single-Step Extraction Coupled with Targeted HILIC-MS/MS Approach for Comprehensive Analysis of Human Plasma Lipidome and Polar Metabolome

Expanding metabolome coverage to include complex lipids and polar metabolites is essential in the generation of well-founded hypotheses in biological assays. Traditionally, lipid extraction is performed by liquid-liquid extraction using either methyl-tert-butyl ether (MTBE) or chloroform, and polar...

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Bibliographic Details
Main Authors: Jessica Medina, Vera van der Velpen, Tony Teav, Yann Guitton, Hector Gallart-Ayala, Julijana Ivanisevic
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Metabolites
Subjects:
sample preparation
extraction
lipidomics
metabolomics
LC-MS/MS
human plasma
Online Access:https://www.mdpi.com/2218-1989/10/12/495

Internet

https://www.mdpi.com/2218-1989/10/12/495

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