T-cell costimulation blockade is effective in experimental digestive and lung tissue fibrosis

T-cell costimulation blockade is effective in experimental digestive and lung tissue fibrosis

Abstract Background We aimed to investigate the efficacy of abatacept in preclinical mouse models of digestive involvement, pulmonary fibrosis, and related pulmonary hypertension (PH), mimicking internal organ involvement in systemic sclerosis (SSc). Methods Abatacept has been evaluated in the chron...

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Bibliographic Details
Main Authors: Gonçalo Boleto, Christophe Guignabert, Sonia Pezet, Anne Cauvet, Jérémy Sadoine, Ly Tu, Carole Nicco, Camille Gobeaux, Frédéric Batteux, Yannick Allanore, Jérôme Avouac
Format: Article
Language:English
Published: BMC 2018-08-01
Series:Arthritis Research & Therapy
Subjects:
Pulmonary fibrosis
Pulmonary hypertension
Gastrointestinal tract involvement
Systemic sclerosis
Abatacept
Online Access:http://link.springer.com/article/10.1186/s13075-018-1694-9

Internet

http://link.springer.com/article/10.1186/s13075-018-1694-9

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