APOE-ε4 allele[s]-associated adverse events reported from placebo arm in clinical trials for Alzheimer's disease: implications for anti-amyloid beta therapy

APOE-ε4 allele[s]-associated adverse events reported from placebo arm in clinical trials for Alzheimer's disease: implications for anti-amyloid beta therapy

APOE-ε4 allele[s] is a risk factor for Alzheimer's disease (AD) and Amyloid-Related Imaging Abnormalities (ARIA) in anti-amyloid beta therapy, and is also associated with cerebrovascular risk factors such as hyperlipidemia or atherosclerosis. During AD clinical trials, APOE-ε4 carriers may expe...

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Bibliographic Details
Main Authors: Kenichiro Sato, Yoshiki Niimi, Ryoko Ihara, Kazushi Suzuki, Atsushi Iwata, Takeshi Iwatsubo
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Dementia
Subjects:
adverse event
APOE
Amyloid-Related Imaging Abnormalities
ARIA
Alzheimer's disease
disease-modifying therapy
Online Access:https://www.frontiersin.org/articles/10.3389/frdem.2023.1320329/full

Internet

https://www.frontiersin.org/articles/10.3389/frdem.2023.1320329/full

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