A defective TLR4 signaling for IFN-β expression is responsible for the innately lower ability of BALB/c macrophages to produce NO in response to LPS as compared to C57BL/6.

A defective TLR4 signaling for IFN-β expression is responsible for the innately lower ability of BALB/c macrophages to produce NO in response to LPS as compared to C57BL/6.

C57BL/6 mice macrophages innately produce higher levels of NO than BALB/c cells when stimulated with LPS. Here, we investigated the molecular events that account for this intrinsic differential production of NO. We found that the lower production of NO in BALB/c is not due to a subtraction of L-argi...

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Bibliographic Details
Main Authors: Luciana S Oliveira, Nina M G P de Queiroz, Laura V S Veloso, Thaís G Moreira, Fernanda S Oliveira, Matheus B H Carneiro, Ana M Faria, Leda Q Vieira, Sérgio C Oliveira, Maria F Horta
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4049611?pdf=render

Internet

http://europepmc.org/articles/PMC4049611?pdf=render

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