Developmental alterations in centrosome integrity contribute to the post-mitotic state of mammalian cardiomyocytes

Developmental alterations in centrosome integrity contribute to the post-mitotic state of mammalian cardiomyocytes

Mammalian cardiomyocytes become post-mitotic shortly after birth. Understanding how this occurs is highly relevant to cardiac regenerative therapy. Yet, how cardiomyocytes achieve and maintain a post-mitotic state is unknown. Here, we show that cardiomyocyte centrosome integrity is lost shortly afte...

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Bibliographic Details
Main Authors: David C Zebrowski, Silvia Vergarajauregui, Chi-Chung Wu, Tanja Piatkowski, Robert Becker, Marina Leone, Sofia Hirth, Filomena Ricciardi, Nathalie Falk, Andreas Giessl, Steffen Just, Thomas Braun, Gilbert Weidinger, Felix B Engel
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-08-01
Series:eLife
Subjects:
cardiomyocyte
newt
primary cilium
MTOC
terminal differentiation
centrosome
Online Access:https://elifesciences.org/articles/05563

Internet

https://elifesciences.org/articles/05563

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