Genetically programmed retinoic acid deficiency during gastrulation phenocopies most known developmental defects due to acute prenatal alcohol exposure in FASD

Genetically programmed retinoic acid deficiency during gastrulation phenocopies most known developmental defects due to acute prenatal alcohol exposure in FASD

Fetal Alcohol Spectrum Disorder (FASD) arises from maternal consumption of alcohol during pregnancy affecting 2%–5% of the Western population. In Xenopus laevis studies, we showed that alcohol exposure during early gastrulation reduces retinoic acid (RA) levels at this critical embryonic stage induc...

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Bibliographic Details
Main Authors: B. Petrelli, A. Oztürk, M. Pind, H. Ayele, A. Fainsod, G. G. Hicks
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
gastrulation
retinoic acid
vitamin A deficiency
fetal alcohol spectrum disorder (FASD)
prenatal alcohol exposure (PAE)
craniofacial malformations
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2023.1208279/full

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https://www.frontiersin.org/articles/10.3389/fcell.2023.1208279/full

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