Global SUMOylation is a Molecular Mechanism Underlying Hypothermia-induced Ischemic Tolerance

Global SUMOylation is a Molecular Mechanism Underlying Hypothermia-induced Ischemic Tolerance

The molecular mechanisms underlying hypothermic neuroprotection have yet to be fully elucidated. Herein we demonstrate that global SUMOylation, a form of post-translational modification with the Small Ubiquitin-like MOdifer, participates in the multimodal molecular induction of hypothermia-induced i...

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Bibliographic Details
Main Authors: Yang-ja eLee, Yongshan eMou, Dace eKlimanis, Joshua D Bernstock, John M. Hallenbeck
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-12-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Sumoylation
Neuroprotection
hypothermia for stroke
Ubc9
oxygen and glucose deprivation
pMCAO
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00416/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00416/full

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