A high interferon gamma signature of CD8+ T cells predicts response to neoadjuvant immunotherapy plus chemotherapy in gastric cancer

A high interferon gamma signature of CD8+ T cells predicts response to neoadjuvant immunotherapy plus chemotherapy in gastric cancer

BackgroundWhile the tumor microenvironment (TME) affects immune checkpoint blockade (ICB) efficacy, ICB also reshapes the characteristics of TME. Thus far, studies have focused on the TME evolution during neoadjuvant or adjuvant ICB therapy in gastric cancer (GC). However, the interaction between TM...

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Bibliographic Details
Main Authors: Sen Li, Ke Li, Fei Tian, Hongle Li, Qingxin Xia, Tiepeng Li, Bing Dong, Danyang Li, Juan Yu, Junli Zhang, Li Wang, Chengjuan Zhang, Shuning Xu, Yuzhou Zhao, Ying Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Immunology
Subjects:
gastric cancer
single-cell RNA sequencing
tumor microenvironment
interferon gamma
immune checkpoint blockade
neoadjuvant immunotherapy
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1056144/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.1056144/full

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