P130Cas Src-binding and substrate domains have distinct roles in sustaining focal adhesion disassembly and promoting cell migration.

P130Cas Src-binding and substrate domains have distinct roles in sustaining focal adhesion disassembly and promoting cell migration.

The docking protein p130Cas is a prominent Src substrate found in focal adhesions (FAs) and is implicated in regulating critical aspects of cell motility including FA disassembly and protrusion of the leading edge plasma membrane. To better understand how p130Cas acts to promote these events we exam...

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Bibliographic Details
Main Authors: Leslie M Meenderink, Larisa M Ryzhova, Dominique M Donato, Daniel F Gochberg, Irina Kaverina, Steven K Hanks
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-10-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2956669?pdf=render

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http://europepmc.org/articles/PMC2956669?pdf=render

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