Novel Inhibitor for Downstream Targeting of Transforming Growth Factor-β Signaling to Suppress Epithelial to Mesenchymal Transition and Cell Migration

Novel Inhibitor for Downstream Targeting of Transforming Growth Factor-β Signaling to Suppress Epithelial to Mesenchymal Transition and Cell Migration

Cancer metastasis accounts for most of the mortality associated with solid tumors. However, antimetastatic drugs are not available on the market. One of the important biological events leading to metastasis is the epithelial to mesenchymal transition (EMT) induced by cytokines, namely transforming g...

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Bibliographic Details
Main Authors: Tsugumasa Toma, Hiroshi Tateishi, Kensaku Kawakami, Taha F. S. Ali, Masahiro Kamo, Kazuaki Monde, Yuta Nakashima, Mikako Fujita, Masami Otsuka
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:International Journal of Molecular Sciences
Subjects:
anti-cell migration
anti-epithelial to mesenchymal transition (EMT)
transforming growth factor-β (TGF-β)
non-small-cell lung cancer (NSCLC) cells
Smad
Online Access:https://www.mdpi.com/1422-0067/23/9/5047

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https://www.mdpi.com/1422-0067/23/9/5047

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