miR-486-5p and miR-22-3p Enable Megakaryocytic Differentiation of Hematopoietic Stem and Progenitor Cells without Thrombopoietin

miR-486-5p and miR-22-3p Enable Megakaryocytic Differentiation of Hematopoietic Stem and Progenitor Cells without Thrombopoietin

Megakaryocytes release submicron size microparticles (MkMPs) in circulation. We have shown that MkMPs target CD34+ hematopoietic stem/progenitor cells (HSPCs) to induce megakaryocytic differentiation, and that small RNAs in MkMPs play an important role in the development of this phenotype. Here, usi...

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Bibliographic Details
Main Authors: Chen-Yuan Kao, Jinlin Jiang, Will Thompson, Eleftherios T. Papoutsakis
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:International Journal of Molecular Sciences
Subjects:
hematopoietic stem/progenitor cells
megakaryopoiesis
megakaryocytic extracellular vesicle
microRNA
signaling
Online Access:https://www.mdpi.com/1422-0067/23/10/5355

Internet

https://www.mdpi.com/1422-0067/23/10/5355

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