RIP140 deficiency enhances cardiac fuel metabolism and protects mice from heart failure

RIP140 deficiency enhances cardiac fuel metabolism and protects mice from heart failure

During the development of heart failure (HF), the capacity for cardiomyocyte (CM) fatty acid oxidation (FAO) and ATP production is progressively diminished, contributing to pathologic cardiac hypertrophy and contractile dysfunction. Receptor-interacting protein 140 (RIP140, encoded by Nrip1) has bee...

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Bibliographic Details
Main Authors: Tsunehisa Yamamoto, Santosh K. Maurya, Elizabeth Pruzinsky, Kirill Batmanov, Yang Xiao, Sarah M. Sulon, Tomoya Sakamoto, Yang Wang, Ling Lai, Kendra S. McDaid, Swapnil V. Shewale, Teresa C. Leone, Timothy R. Koves, Deborah M. Muoio, Pieterjan Dierickx, Mitchell A. Lazar, E. Douglas Lewandowski, Daniel P. Kelly
Format: Article
Language:English
Published: American Society for Clinical Investigation 2023-05-01
Series:The Journal of Clinical Investigation
Subjects:
Cardiology
Online Access:https://doi.org/10.1172/JCI162309

Internet

https://doi.org/10.1172/JCI162309

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