Chromatin mapping and single-cell immune profiling define the temporal dynamics of ibrutinib response in CLL

Chromatin mapping and single-cell immune profiling define the temporal dynamics of ibrutinib response in CLL

Ibrutinib, a Bruton tyrosine kinase inhibitor, provides effective treatment for chronic lymphocytic leukemia (CLL). Here, the authors describe time-dependent molecular changes to malignant cells and to the immune system in patients undergoing ibrutinib therapy, with can be used for therapy monitorin...

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Bibliographic Details
Main Authors: André F. Rendeiro, Thomas Krausgruber, Nikolaus Fortelny, Fangwen Zhao, Thomas Penz, Matthias Farlik, Linda C. Schuster, Amelie Nemc, Szabolcs Tasnády, Marienn Réti, Zoltán Mátrai, Donát Alpár, Csaba Bödör, Christian Schmidl, Christoph Bock
Format: Article
Language:English
Published: Nature Portfolio 2020-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-14081-6

Internet

https://doi.org/10.1038/s41467-019-14081-6

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