DHW-221, a Dual PI3K/mTOR Inhibitor, Overcomes Multidrug Resistance by Targeting P-Glycoprotein (P-gp/ABCB1) and Akt-Mediated FOXO3a Nuclear Translocation in Non-small Cell Lung Cancer

DHW-221, a Dual PI3K/mTOR Inhibitor, Overcomes Multidrug Resistance by Targeting P-Glycoprotein (P-gp/ABCB1) and Akt-Mediated FOXO3a Nuclear Translocation in Non-small Cell Lung Cancer

Multidrug resistance (MDR) is considered as a primary hindrance for paclitaxel failure in non-small cell lung cancer (NSCLC) patients, in which P-glycoprotein (P-gp) is overexpressed and the PI3K/Akt signaling pathway is dysregulated. Previously, we designed and synthesized DHW-221, a dual PI3K/mTOR...

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Bibliographic Details
Main Authors: Mingyue Liu, Chang Xu, Xiaochun Qin, Wenwu Liu, Deping Li, Hui Jia, Xudong Gao, Yuting Wu, Qiong Wu, Xiangbo Xu, Bo Xing, Xiaowen Jiang, Hongyuan Lu, Yingshi Zhang, Huaiwei Ding, Qingchun Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Oncology
Subjects:
NSCLC
P-glycoprotein
FOXO3a nuclear translocation
Multidrug resistance
DHW-221
paraptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.873649/full

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https://www.frontiersin.org/articles/10.3389/fonc.2022.873649/full

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