Captopril oral solution for pediatric use: formulation, stability study and palatability assessment in vivo

Captopril oral solution for pediatric use: formulation, stability study and palatability assessment in vivo

Abstract The aim of this work was to develop an oral solution of captopril at 5 mg/mL preservative-free. Two formulations were prepared, one containing sweetener (formulation 1) and the other without this excipient (formulation 2). The results found of validation parameters from analytical method pe...

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Bibliographic Details
Main Authors: Leticia Pereira Dysarz, Melanie Tavares, Alessandra Lifsitch Viçosa, Mara Fernandes Ribeiro, Rafaela Gomes de Silva Teixeira, Sabrina Calil Elias, Márcio Robert Mattos da Silva, Elisabete Pereira dos Santos, Eduardo Ricci-Júnior
Format: Article
Language:English
Published: Universidade de São Paulo 2022-05-01
Series:Brazilian Journal of Pharmaceutical Sciences
Subjects:
Captopril
Oral liquid
Pediatrics
Drug stability
Taste
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502022000100573&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502022000100573&lng=en&tlng=en

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