Inhibitory role of Annexin A1 in pathological bone resorption and therapeutic implications in periprosthetic osteolysis

Inhibitory role of Annexin A1 in pathological bone resorption and therapeutic implications in periprosthetic osteolysis

Periprosthetic osteolysis is a cause of arthroplasty failure without available therapies. Here the authors show that Annexin A1 (AnxA1) is involved in in periprosthetic osteolysis and exerts potential therapeutic effects through suppressing NFκB signaling and promoting the PPAR-γ pathway resulting i...

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Detalles Bibliográficos
Autores principales: Hend Alhasan, Mohamad Alaa Terkawi, Gen Matsumae, Taku Ebata, Yuan Tian, Tomohiro Shimizu, Yoshio Nishida, Shunichi Yokota, Fayna Garcia-Martin, Mahmoud M. Abd Elwakil, Daisuke Takahashi, Mahmoud A. Younis, Hideyoshi Harashima, Ken Kadoya, Norimasa Iwasaki
Formato: Artículo
Lenguaje:English
Publicado: Nature Portfolio 2022-07-01
Colección:Nature Communications
Acceso en línea:https://doi.org/10.1038/s41467-022-31646-0

Internet

https://doi.org/10.1038/s41467-022-31646-0

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