Vangl2 disruption alters the biomechanics of late spinal neurulation leading to spina bifida in mouse embryos

Vangl2 disruption alters the biomechanics of late spinal neurulation leading to spina bifida in mouse embryos

Human mutations in the planar cell polarity component VANGL2 are associated with the neural tube defect spina bifida. Homozygous Vangl2 mutation in mice prevents initiation of neural tube closure, precluding analysis of its subsequent roles in neurulation. Spinal neurulation involves rostral-to-caud...

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Bibliographic Details
Main Authors: Gabriel L. Galea, Oleksandr Nychyk, Matteo A. Mole, Dale Moulding, Dawn Savery, Evanthia Nikolopoulou, Deborah J. Henderson, Nicholas D. E. Greene, Andrew J. Copp
Format: Article
Language:English
Published: The Company of Biologists 2018-03-01
Series:Disease Models & Mechanisms
Subjects:
Neural tube
Vangl2
Biomechanics
F-actin
Mouse
Embryo
Online Access:http://dmm.biologists.org/content/11/3/dmm032219

Internet

http://dmm.biologists.org/content/11/3/dmm032219

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