Effect of sodium (S)-2-hydroxyglutarate in male, and succinic acid in female Wistar rats against renal ischemia-reperfusion injury, suggesting a role of the HIF-1 pathway

Effect of sodium (S)-2-hydroxyglutarate in male, and succinic acid in female Wistar rats against renal ischemia-reperfusion injury, suggesting a role of the HIF-1 pathway

Background Ischemia–reperfusion (IR) injury is the main cause of delayed graft function in solid organ transplantation. Hypoxia-inducible factors (HIFs) control the expression of genes related to preconditioning against IR injury. During normoxia, HIF-α subunits are marked for degradation by the egg...

Full description

Bibliographic Details
Main Authors: Eduardo Cienfuegos-Pecina, Tannya R. Ibarra-Rivera, Alma L. Saucedo, Luis A. Ramírez-Martínez, Deanna Esquivel-Figueroa, Ixel Domínguez-Vázquez, Karina J. Alcántara-Solano, Diana P. Moreno-Peña, Gabriela Alarcon-Galvan, Diana Raquel Rodríguez-Rodríguez, Liliana Torres-González, Linda E. Muñoz-Espinosa, Edelmiro Pérez-Rodríguez, Paula Cordero-Pérez
Format: Article
Language:English
Published: PeerJ Inc. 2020-07-01
Series:PeerJ
Subjects:
Ischemia-reperfusion injury
Hypoxia-inducible factors
EGLN prolyl-4-hydroxylases
2-hydroxyglutarate
Succinic acid
Kidney
Online Access:https://peerj.com/articles/9438.pdf

Internet

https://peerj.com/articles/9438.pdf

Similar Items