Synthesis of New 1H-1,2,3-Triazole Analogs in Aqueous Medium via “Click” Chemistry: A Novel Class of Potential Carbonic Anhydrase-II Inhibitors

Synthesis of New 1H-1,2,3-Triazole Analogs in Aqueous Medium via “Click” Chemistry: A Novel Class of Potential Carbonic Anhydrase-II Inhibitors

A series of novel 1H-1,2,3-triazole analogs (9a–j) were synthesized via “Click” chemistry and Suzuki–Miyaura cross-coupling reaction in aqueous medium. The compounds were evaluated for their carbonic anhydrase-II enzyme inhibitory activity in vitro. The synthesis of triazole 7a was accomplished usin...

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Bibliographic Details
Main Authors: Satya Kumar Avula, Majid Khan, Sobia Ahsan Halim, Ajmal Khan, Samia Ahmed Al-Riyami, Rene Csuk, Biswanath Das, Ahmed Al-Harrasi
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Chemistry
Subjects:
synthesis
1H-1, 2, 3-triazole analogs
click chemistry
aqueous medium
carbonic anhydrase-II inhibitory activity
molecular docking studies
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2021.642614/full

Internet

https://www.frontiersin.org/articles/10.3389/fchem.2021.642614/full

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