Inhibition of USP14 enhances the sensitivity of breast cancer to enzalutamide

Inhibition of USP14 enhances the sensitivity of breast cancer to enzalutamide

Abstract Background Androgen receptor (AR) is expressed in approximately 70% of breast tumors. Recent studies increasingly support AR as a potential therapeutic target of AR-positive breast cancer. We have previously reported that deubiquitinase USP14 stabilizes AR proteins by deubiquitination and U...

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Bibliographic Details
Main Authors: Xiaohong Xia, Chuyi Huang, Yuning Liao, Yuan Liu, Jinchan He, Zhiqiang Guo, Lili Jiang, Xuejun Wang, Jinbao Liu, Hongbiao Huang
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Breast cancer
Enzalutamide
USP14
Androgen receptor
Combination treatment
Online Access:http://link.springer.com/article/10.1186/s13046-019-1227-7

Internet

http://link.springer.com/article/10.1186/s13046-019-1227-7

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