Intratumor childhood vaccine-specific CD4+ T-cell recall coordinates antitumor CD8+ T cells and eosinophils

Background Antitumor mechanisms of CD4+ T cells remain crudely defined, and means to effectively harness CD4+ T-cell help for cancer immunotherapy are lacking. Pre-existing memory CD4+ T cells hold potential to be leveraged for this purpose. Moreover, the role of pre-existing immunity in virotherapy...

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Bibliographic Details
Main Authors: Daniel Landi, Annick Desjardins, Matthias Gromeier, Darell D Bigner, Smita K Nair, Michael C Brown, Georgia M Beasley, David M Ashley, Yuanfan Yang, Zachary P McKay, Dina M Randazzo
Format: Article
Language:English
Published: BMJ Publishing Group 2023-04-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/11/4/e006463.full