The ETV6-MECOM fusion protein promotes EMT-related properties by repressing the transactivation activity of E-cadherin promoter in K562 leukemia cells

The ETV6-MECOM fusion protein promotes EMT-related properties by repressing the transactivation activity of E-cadherin promoter in K562 leukemia cells

The ETV6-MECOM fusion gene, produced by the rare and recurrent chromosomal translocation t(3; 12) (q26; p13), is associated with high mortality and short survival in myeloid leukemia. However, its function and underlying mechanisms in leukemia progression remain unknown. In this study, leukemia-stab...

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Bibliographic Details
Main Authors: Qian Li, Furong Wang, Xuehong Zhang, Shuqing Liu, Ming-Zhong Sun, Jinsong Yan
Format: Article
Language:English
Published: Elsevier 2024-07-01
Series:Biochemistry and Biophysics Reports
Subjects:
ETV6-MECOM
E-cadherin promoter
EMT
Transactivation
Leukemia
Online Access:http://www.sciencedirect.com/science/article/pii/S2405580824000311

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http://www.sciencedirect.com/science/article/pii/S2405580824000311

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