A non-toxic equinatoxin-II reveals the dynamics and distribution of sphingomyelin in the cytosolic leaflet of the plasma membrane

A non-toxic equinatoxin-II reveals the dynamics and distribution of sphingomyelin in the cytosolic leaflet of the plasma membrane

Abstract Sphingomyelin (SM) is a major sphingolipid in mammalian cells. SM is enriched in the extracellular leaflet of the plasma membrane (PM). Besides this localization, recent electron microscopic and biochemical studies suggest the presence of SM in the cytosolic leaflet of the PM. In the presen...

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Bibliographic Details
Main Authors: Toshiki Mori, Takahiro Niki, Yasunori Uchida, Kojiro Mukai, Yoshihiko Kuchitsu, Takuma Kishimoto, Shota Sakai, Asami Makino, Toshihide Kobayashi, Hiroyuki Arai, Yasunari Yokota, Tomohiko Taguchi, Kenichi G. N. Suzuki
Format: Article
Language:English
Published: Nature Portfolio 2024-07-01
Series:Scientific Reports
Subjects:
Nontoxic equinatoxin-II variant
Sphingomyelin
Rafts
Inner leaflet
Super-resolution microscopy
Single molecule imaging
Online Access:https://doi.org/10.1038/s41598-024-67803-2

Internet

https://doi.org/10.1038/s41598-024-67803-2

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