Allosteric cross-talk between the hydrophobic cleft and the BH4 domain of Bcl-2 in control of inositol 1,4,5-trisphosphate receptor activity

Allosteric cross-talk between the hydrophobic cleft and the BH4 domain of Bcl-2 in control of inositol 1,4,5-trisphosphate receptor activity

Aim: Inositol 1,4,5-trisphosphate receptor (IP3R) is a ubiquitous calcium (Ca2+) channel involved in the regulation of cellular fate and motility. Its modulation by anti-apoptotic protein B-cell lymphoma 2 (Bcl-2) plays an important role in cancer progression. Disrupting this interaction could over...

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Bibliographic Details
Main Authors: George Shapovalov, Abigaël Ritaine, Nadege Charlene Essonghe, Ian de Ridder, Hristina Ivanova, Spyridoula Karamanou, Anastassios Economou, Geert Bultynck, Roman Skryma, Natalia Prevarskaya
Format: Article
Language:English
Published: Open Exploration Publishing Inc. 2022-06-01
Series:Exploration of Targeted Anti-tumor Therapy
Subjects:
cancer
calcium
bcl-2
ip3r
organelle membrane-derived patch-clamp
molecular dynamics
Online Access:https://www.explorationpub.com/Journals/etat/Article/100288

Internet

https://www.explorationpub.com/Journals/etat/Article/100288

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