Uric Acid Reacts with Peroxidasin, Decreases Collagen IV Crosslink, Impairs Human Endothelial Cell Migration and Adhesion

Uric Acid Reacts with Peroxidasin, Decreases Collagen IV Crosslink, Impairs Human Endothelial Cell Migration and Adhesion

Uric acid is considered the main substrate for peroxidases in plasma. The oxidation of uric acid by human peroxidases generates urate free radical and urate hydroperoxide, which might affect endothelial function and explain, at least in part, the harmful effects of uric acid on the vascular system....

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Bibliographic Details
Main Authors: Bianca Dempsey, Litiele Cezar Cruz, Marcela Franco Mineiro, Railmara Pereira da Silva, Flavia Carla Meotti
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Antioxidants
Subjects:
peroxidasin
uric acid
oxidation
HUVEC
extracellular matrix
collagen IV
Online Access:https://www.mdpi.com/2076-3921/11/6/1117

Internet

https://www.mdpi.com/2076-3921/11/6/1117

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