Combined Treatment with KV Channel Inhibitor 4-Aminopyridine and either γ-Cystathionine Lyase Inhibitor β-Cyanoalanine or Epinephrine Restores Blood Pressure, and Improves Survival in the Wistar Rat Model of Anaphylactic Shock

Combined Treatment with KV Channel Inhibitor 4-Aminopyridine and either γ-Cystathionine Lyase Inhibitor β-Cyanoalanine or Epinephrine Restores Blood Pressure, and Improves Survival in the Wistar Rat Model of Anaphylactic Shock

The mechanism of anaphylactic shock (AS) remains incompletely understood. The potassium channel blocker 4-aminopyridine (4-AP), the inhibitors of cystathionine γ-lyase (ICSE), dl-propargylglycine (DPG) or β-cyanoalanine (BCA), and the nitric oxide (NO) synthase produce vasoconstriction and could be...

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Bibliographic Details
Main Authors: Abdelouahab Bellou, Nacira Sennoun, Elhadi H. Aburawi, Richard L. Jayaraj, Seth L. Alper, Ibrahim Abdallah Alfaki, Javed Yasin, Subramanian Sekar, Mohamed Shafiuallah, Suhail Al-Salam, Abderrahim Nemmar, Elsadig Kazzam, Paul Michel Mertes, Suleiman Al-Hammadi
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Biology
Subjects:
anaphylactic shock
Voltage-dependent K+ channel
4-aminopyridine
β-cyanoalanine
dl-propargylglycine
angiotensin II
Online Access:https://www.mdpi.com/2079-7737/11/10/1455

Internet

https://www.mdpi.com/2079-7737/11/10/1455

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