Alterations of the expression of TET2 and DNA 5-hmC predict poor prognosis in Myelodysplastic Neoplasms

Alterations of the expression of TET2 and DNA 5-hmC predict poor prognosis in Myelodysplastic Neoplasms

Abstract Background Myelodysplastic Neoplasms (MDS) are clonal stem cell disorders characterized by ineffective hematopoiesis and progression to acute myeloid leukemia, myelodysplasia-related (AML-MR). A major mechanism of pathogenesis of MDS is the aberration of the epigenetic landscape of the hema...

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Bibliographic Details
Main Authors: Ashikh A. Seethy, Karthikeyan Pethusamy, Tushar Kushwaha, Gaurav Kumar, Joyeeta Talukdar, Rekha Chaubey, Udayakumar Dharmalingam Sundaram, Manoranjan Mahapatra, Renu Saxena, Ruby Dhar, Krishna K. Inampudi, Subhradip Karmakar
Format: Article
Language:English
Published: BMC 2023-10-01
Series:BMC Cancer
Subjects:
Myelodysplastic neoplasms
Myelodysplastic syndrome
AML-myelodysplasia related
Acute myeloid leukemia with myelodysplasia related changes
Epigenetics
TET2 protein
Online Access:https://doi.org/10.1186/s12885-023-11449-2

Internet

https://doi.org/10.1186/s12885-023-11449-2

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