Haplotype-specific MAPT exon 3 expression regulated by common intronic polymorphisms associated with Parkinsonian disorders

Haplotype-specific MAPT exon 3 expression regulated by common intronic polymorphisms associated with Parkinsonian disorders

Abstract Background Genome wide association studies have identified microtubule associated protein tau (MAPT) H1 haplotype single nucleotide polymorphisms (SNPs) as leading common risk variants for Parkinson’s disease, progressive supranuclear palsy and corticobasal degeneration. The MAPT risk varia...

Full description

Bibliographic Details
Main Authors: Mang Ching Lai, Anne-Laure Bechy, Franziska Denk, Emma Collins, Maria Gavriliouk, Judith B. Zaugg, Brent J. Ryan, Richard Wade-Martins, Tara M. Caffrey
Format: Article
Language:English
Published: BMC 2017-10-01
Series:Molecular Neurodegeneration
Subjects:
Tau
Progressive supranuclear palsy
Alzheimer’s disease
MAPT
Corticobasal degeneration
Parkinson’s disease
Online Access:http://link.springer.com/article/10.1186/s13024-017-0224-6

Internet

http://link.springer.com/article/10.1186/s13024-017-0224-6

Similar Items