Hyaluronic acid-ibuprofen conjugation: a novel ototherapeutic approach protecting inner ear cells from inflammation-mediated damage

There is a substantial need of effective drugs for the treatment of hearing loss, which affects nearly 500 million individuals globally. Hearing loss can be the result of intense or prolonged noise exposure, ototoxic drugs, infections, and trauma, which trigger inflammatory signaling cascades that l...

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Bibliographic Details
Main Authors: Bhaskar Birru, Joachim G. S. Veit, Elizabeth M. Arrigali, Jack Van Tine, Emma Barrett-Catton, Zachary Tonnerre, Philippe Diaz, Monica A. Serban
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Pharmacology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1355283/full