Pharmacological Inhibition of CA-IX Impairs Tumor Cell Proliferation, Migration and Invasiveness

Pharmacological Inhibition of CA-IX Impairs Tumor Cell Proliferation, Migration and Invasiveness

Carbonic anhydrase IX (CA-IX) plays a pivotal role in regulation of pH in tumor milieu catalyzing carbonic acid formation by hydrating CO<sub>2</sub>. An acidification of tumor microenvironment contributes to tumor progression via multiple processes, including reduced cell-cell adhesion,...

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Bibliographic Details
Main Authors: Valerio Ciccone, Arianna Filippelli, Andrea Angeli, Claudiu T. Supuran, Lucia Morbidelli
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:International Journal of Molecular Sciences
Subjects:
Carbonic anhydrase IX
cancer cells
apoptosis
epithelial-mesenchymal transition
invasiveness
Online Access:https://www.mdpi.com/1422-0067/21/8/2983

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https://www.mdpi.com/1422-0067/21/8/2983

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