Influence of Desialylation on the Drug Binding Affinity of Human Alpha-1-Acid Glycoprotein Assessed by Microscale Thermophoresis

Influence of Desialylation on the Drug Binding Affinity of Human Alpha-1-Acid Glycoprotein Assessed by Microscale Thermophoresis

Human serum alpha-1-acid glycoprotein (AAG) is an acute-phase plasma protein involved in the binding and transport of many drugs, especially basic and lipophilic substances. The sialic acid groups that terminate the N-glycan chains of AAG have been reported to change in response to numerous health c...

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Bibliographic Details
Main Authors: Tino Šeba, Robert Kerep, Tin Weitner, Dinko Šoić, Toma Keser, Gordan Lauc, Mario Gabričević
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:Pharmaceutics
Subjects:
alpha-1-acid glycoprotein
plasma protein binding
equilibrium binding affinity
desialylation
microscale thermophoresis
Online Access:https://www.mdpi.com/1999-4923/16/2/230

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https://www.mdpi.com/1999-4923/16/2/230

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