PTPN2 targets TAK1 for dephosphorylation to improve cellular senescence and promote adipose tissue browning in T2DM

PTPN2 targets TAK1 for dephosphorylation to improve cellular senescence and promote adipose tissue browning in T2DM

Introduction: The energy imbalance when energy intake exceeds expenditure acts as an essential factor in the development of insulin resistance (IR). The activity of brown adipose tissue, which is involved in the dissipation of energy via heat expenditure decreases under type 2 diabetic mellitus (T2D...

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Bibliographic Details
Main Authors: Yapeng Liu, Lu Han, Ping Zhu, Ming Song, Yaoyuan Zhang, Linlin Meng, Wei Zhang, Cheng Zhang, Ming Zhong
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Pharmacology
Subjects:
PTPN2
TAK1
adipocytes
senescence
adipose tissue browning
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1124633/full

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https://www.frontiersin.org/articles/10.3389/fphar.2023.1124633/full

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