Sensory Neuron-Specific Deletion of Tropomyosin Receptor Kinase A (<i>TrkA</i>) in Mice Abolishes Osteoarthritis (OA) Pain via NGF/TrkA Intervention of Peripheral Sensitization

Sensory Neuron-Specific Deletion of Tropomyosin Receptor Kinase A (<i>TrkA</i>) in Mice Abolishes Osteoarthritis (OA) Pain via NGF/TrkA Intervention of Peripheral Sensitization

Tropomyosin receptor kinase A (TrkA/NTRK1) is a high-affinity receptor for nerve growth factor (NGF), a potent pain mediator. NGF/TrkA signaling elevates synovial sensory neuronal distributions in the joints and causes osteoarthritis (OA) pain. We investigated the mechanisms of pain transmission as...

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Bibliographic Details
Main Authors: InSug O-Sullivan, Ranjan Kc, Gurjit Singh, Vaskar Das, Kaige Ma, Xin Li, Fackson Mwale, Gina Votta-Velis, Benjamin Bruce, Arivarasu Natarajan Anbazhagan, Andre J. van Wijnen, Hee-Jeong Im
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:International Journal of Molecular Sciences
Subjects:
osteoarthritis
NGF/TrkA signaling
pain transportation
hyperalgesia
cellular plasticity
Online Access:https://www.mdpi.com/1422-0067/23/20/12076

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https://www.mdpi.com/1422-0067/23/20/12076

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