Tenofovir Modulates Semaphorin 4D Signaling and Regulates Bone Homeostasis, Which Can Be Counteracted by Dipyridamole and Adenosine A2A Receptor

Tenofovir Modulates Semaphorin 4D Signaling and Regulates Bone Homeostasis, Which Can Be Counteracted by Dipyridamole and Adenosine A2A Receptor

Semaphorin 4D (Sema4D) is a neurotrophin that is secreted by osteoclasts and binds to its receptor PlexinB1 on osteoblasts to inhibit their differentiation and function. Adenosine A2A activation inhibits osteoclast Sema4D-mediated secretion, diminishes inflammatory osteolysis and prevents bone loss...

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Bibliographic Details
Main Authors: Patricia Llamas-Granda, Laura Martin-Rodríguez, Raquel Largo, Gabriel Herrero-Beaumont, Aránzazu Mediero
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:International Journal of Molecular Sciences
Subjects:
Sema4D
tenofovir
bone turnover
HIV
adenosine A2A receptor
osteoblast
Online Access:https://www.mdpi.com/1422-0067/22/21/11490

Internet

https://www.mdpi.com/1422-0067/22/21/11490

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