Engineered neurogenesis in naïve adult rat cortex by Ngn2-mediated neuronal reprogramming of resident oligodendrocyte progenitor cells

Engineered neurogenesis in naïve adult rat cortex by Ngn2-mediated neuronal reprogramming of resident oligodendrocyte progenitor cells

Adult tissue stem cells contribute to tissue homeostasis and repair but the long-lived neurons in the human adult cerebral cortex are not replaced, despite evidence for a limited regenerative response. However, the adult cortex contains a population of proliferating oligodendrocyte progenitor cells...

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Bibliographic Details
Main Authors: Stanley F. Bazarek, Mentor Thaqi, Patrick King, Amol R. Mehta, Ronil Patel, Clark A. Briggs, Emily Reisenbigler, Jonathon E. Yousey, Elis A. Miller, Grace E. Stutzmann, Robert A. Marr, Daniel A. Peterson
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Neuroscience
Subjects:
oligodendrocyte precursor cell
NeuroD1 transcription factor
Neurogenin 2
NG2 cell
reprogramming and differentiation
neuronal replacement
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2023.1237176/full

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https://www.frontiersin.org/articles/10.3389/fnins.2023.1237176/full

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