Modeling Patient-Specific Muscular Dystrophy Phenotypes and Therapeutic Responses in Reprogrammed Myotubes Engineered on Micromolded Gelatin Hydrogels

Modeling Patient-Specific Muscular Dystrophy Phenotypes and Therapeutic Responses in Reprogrammed Myotubes Engineered on Micromolded Gelatin Hydrogels

In vitro models of patient-derived muscle allow for more efficient development of genetic medicines for the muscular dystrophies, which often present mutation-specific pathologies. One popular strategy to generate patient-specific myotubes involves reprogramming dermal fibroblasts to a muscle lineag...

Full description

Bibliographic Details
Main Authors: Florian Barthélémy, Jeffrey W. Santoso, Laura Rabichow, Rongcheng Jin, Isaiah Little, Stanley F. Nelson, Megan L. McCain, M. Carrie Miceli
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
DMD
LGMD
exon skipping
hydrogels
calpain 3
dystrophin
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.830415/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2022.830415/full

Similar Items